Current event #2
"Blocking Pain Receptors Extends Lifespan, Boosts Metabolism in Mice." ScienceDaily. ScienceDaily, 22 May 2014. Web. 25 May 2014.
There was a study done at the University of California, in Berkeley, about the fact that blocking the pain receptor in mice not only extends their lifespan, but also provides them with a more beneficial metabolism. The reason that scientists decided to do an experiment on blocking the pain receptors is chronic pain is known to shorten your life, and as you get older pain tends to increase. "Our findings suggest that pharmacological manipulation of TRPV1 and CGRP may improve metabolic health and longevity," said Dillin, who is a Howard Hughes Medical Institute investigator and the Thomas and Stacey Siebel Distinguished Chair in Stem Cell Research. TRPBI is a pain receptor and it stands for, transient receptor potential cation channel subfamily V member 1. One fact that I learned from this article is, that by constantly activating the pain receptor on a nerve cell, will cause the death of neurons. I also learned that mice lacking the capsaicin pain receptor live around 14 percent longer than normal mice; also they retain a more youthful metabolism as well.
This study is useful to society because it reveals a way that humans can stay healthy. This study is not just useful for relieving pain, but for improving lifespan and metabolic health, and in particular for treating diabetes and obesity. Therefore the article can help prevent people from getting diabetes and obesity. Also, this article mentions an anti-migraine drug that is on the market that inhibits a protein called CGRP,calcitonin gene-related peptide, which blocks insulin release, that is triggered by TRPV1. It results in similar effects to that caused by blocking TRPV1. Dillin revealed that when this drug was given to older mice it restored their metabolic health.
I enjoyed reading this article because it helped educate me on a topic I was not familiar with. I like how in the article they give an example about a food that people eat that has a capsaicin pain receptor, chili peppers. Therefore people can understand where this type of pain receptor can be found. Also, it was helpful that when there were any abbreviations they were explained. Also, this article was very informative, and I was able to learn a lot. However, I felt that the article was repetitive and confusing at times.