"Sepsis Study Comparing Three Treatment Methods Shows Same Survival Rate." U.S National Library of Medicine. U.S. National Library of Medicine, 18 Mar. 2014. Web. 28 Mar. 2014. <http://www.nih.gov/news/health/mar2014/nigms-18.htm>.
Sepsis is a dangerous inflation of everything in the body caused by infections, usually in hospitals. This article was about a clinical trial to try to prevent sepsis from occurring in so many patients. In America alone, sepsis takes 800,000 lives a year. Sepsis can cause dangerously low blood pressure and can cut off your organs’ supply of oxygen, which leads to organ failure and, subsequently, death. Doctors Derek C. Angus, M.D., M.P.H., and Donald M. Yealy, M.D., joined together to start a five-year clinical trial called Protocolized Care for Early Septic Shock (ProCESS) to see how sepsis could be treated. They got 1,341 patients to partake in the trial, divided them into three groups, and tested three different ways of treating sepsis. Group 1 got early goal-directed therapy, which means the doctors inserted a venous catheter near the heart to monitor blood pressure and oxygen levels. Doctors closely monitored the patient for the first 6 hours and gave the patient limited amount of fluids, cardiovascular drugs, and blood transfusions. Group 2 was given protocolized standard care. The patients’ heart rate and blood pressure were taken with a cuff and they were observed without a catheter to decide their treatment plan. The 3rd group was given standard care, which entails the doctors monitoring the patient and giving them drugs, fluids, and transfusions as they saw fit. Dr. Angus and Dr. Yealy compared the results of the 5-year trial and the different methods of care and found that all three treatment plans gave the same outcomes. The outcomes took in all factors of the trial: survival at 60 days, 90 days and one year, heart and lung function, and length of hospital stay. A lot was discovered from this trial, such as the fact that invasive care is not necessary to treat early sepsis. Invasive treatment is dangerous for patients and can cause more infection.
The ProCESS study was a good step towards treating sepsis and avoiding the many deaths it causes yearly. With the information gained from this study, doctors in the future can create new studies with other approaches and perhaps discover the ultimate cure for sepsis. Doctors are one step closer to finding a solution to the danger of sepsis. ProCESS was a successful trial because it determined the level of invasiveness needed to treat early sepsis, and that alone can save many lives by protecting patients from needless infections and strain on their body from the invasive procedures.
This article was very helpful and informational. It gave all the details needed such as the exact methods of care given to the three patient groups. I thought it was well written and well and clearly conveyed the importance and outcome of the ProCESS trial. It was not very informational when it talked about where in the world the trial was performed and what the patients’ conditions were. Some patients may have had different circumstances and medical history, etc. which could affect the trial’s outcomes. Nevertheless, this article was interesting to read and noteworthy in the world of medical science.